Association of the mutations in the human mitochondrial genome with chronic non-inflammatory diseases: type 2 diabetes, hypertension and different types of cardiomyopathy

Authors

  • A.V. Zhelankin The Institute for General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia; Institute for Atherosclerosis Research, Russian Academy of Natural Sciences, postbox 21, Moscow, Russia
  • M.A. Sazonova The Institute for General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia; Russian Cardiology Research Center, 15a, 3rd Cherepkovskaya str., Moscow, 121552, Russia

Keywords:

mitochondrial genome, type 2 diabetes, hypertension, cardiomyopathy

Abstract

Genetic predisposition is of great importance among other risk factors of certain socially significant chronic non-inflammatory diseases. Changes in both nuclear and mitochondrial human genome may play a role in the development of these diseases. Recent studies have shown that mutations in the mitochondrial genome are associated with some diseases, such as type 2 diabetes, hypertension, and various types of cardiomyopathy. Maternal inheritance in some cases suggests that their cause may be precisely the defects of mitochondrial DNA.

Downloads

Published

20-12-2012

Issue

Vol. 56 No. 3 (2012)

Section

Reviews

How to Cite

[1]
2012. Association of the mutations in the human mitochondrial genome with chronic non-inflammatory diseases: type 2 diabetes, hypertension and different types of cardiomyopathy. Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 56, 3 (Dec. 2012), 123–128.

Most read articles by the same author(s)