Association of the mutations in the human mitochondrial genome with chronic non-inflammatory diseases: type 2 diabetes, hypertension and different types of cardiomyopathy

Abstract

Genetic predisposition is of great importance among other risk factors of certain socially significant chronic non-inflammatory diseases. Changes in both nuclear and mitochondrial human genome may play a role in the development of these diseases. Recent studies have shown that mutations in the mitochondrial genome are associated with some diseases, such as type 2 diabetes, hypertension, and various types of cardiomyopathy. Maternal inheritance in some cases suggests that their cause may be precisely the defects of mitochondrial DNA.