Патофизиологические и молекулярные механизмы резорбции белков внеклеточного матрикса при старении кожи и пути их восстановления

Anastasia A. Gorkun; Kristina V. Kozhina; Irina M. Zurina; Nastasia V. Kosheleva; Irina N. Saburina

Pathophysiological and molecular mechanisms of extracellular matrix protein resorption during skin aging, and the ways to their restoration

Anastasia A. Gorkun Institute of General Pathology and Pathophysiology, Moscow http://orcid.org/0000-0001-5859-812X
Kristina V. Kozhina Institute of General Pathology and Pathophysiology, Moscow
Irina M. Zurina Institute of General Pathology and Pathophysiology, Moscow http://orcid.org/0000-0002-3275-0215
Nastasia V. Kosheleva Institute of General Pathology and Pathophysiology, Moscow http://orcid.org/0000-0002-2665-4972
Irina N. Saburina Institute of General Pathology and Pathophysiology, Moscow; Russian Medical Academy of Postgraduate Education, Moscow http://orcid.org/0000-0003-2014-2535

Keywords: skin aging, oxidative stress, extracellular matrix, Warton’s jelly.

Abstract

The article is a short review of the most studied molecular mechanisms leading to skin aging. It considers mechanisms of cellular aging, oxidative stress, development of chronic inflammation, as well as synthesis and degradation of extracellular matrix proteins. The review also contains examples of extracellular matrix restoration using cell and pharmacological technologies

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Published

2016-11-21

How to Cite

Gorkun A. A., Kozhina K. V., Zurina I. M., Kosheleva N. V., Saburina I. N. Pathophysiological and molecular mechanisms of extracellular matrix protein resorption during skin aging, and the ways to their restoration // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2016. VOL. 60. № 4. PP. 128–133.

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Issue

Vol. 60 No. 4 (2016)

Section

Reviews

Pathophysiological and molecular mechanisms of extracellular matrix protein resorption during skin aging, and the ways to their restoration

Abstract

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