Index assessment of parameters of the cardiovascular system functioning in post-stroke patients

  • Kirill Petrovich Ivanov Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 25 Petrovka St., Moscow 107031, Russian Federation; Institute of Biomedical Problems of the Russian Academy of Sciences, 76A Khoroshevskoe Shosse, Moscow 123007, Russian Federation https://orcid.org/0009-0000-9569-2246
  • Vladimir Terentyevich Dolgikh Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 25 Petrovka St., Moscow 107031, Russian Federation https://orcid.org/0000-0001-9034-4912
Keywords: ischemic stroke, cardiovascular system, hemodynamic indices, post-stroke rehabilitation

Abstract

Introduction. Objective characteristics of the cardiovascular system (CVS) functioning are important indicators of the physiological state and adaptive reserves of the human body. Aim. Index assessment of the state of peripheral circulation and parameters of the balance between the CVS cardiac and vascular components during the 2nd stage of rehabilitation in patients after ischemic stroke depending on their gender and age.

Methods. The CVS functional state was studied in 66 patients aged 41 to 83 years at the 2nd stage of rehabilitation after ischemic stroke. The patients underwent a rehabilitation program daily for 2 weeks, including exercise therapy using additional mechanical therapeutic devices, therapeutic massage, equipment-based physiotherapy, and drug therapy. On days 1 and 10 of the rehabilitation treatment, daily Holter monitoring of electrocardiogram and blood pressure was performed. Heart rate (HR) and blood pressure (BP) parameters were recorded. To assess the dynamics of the CVS functional state and adaptive potential, CVS function indices were calculated.

Results. An integrated assessment of the CVS functional state allows analyzing the mobilization of the body's adaptive capabilities during rehabilitation treatment. The values of the physiological normal range of hemodynamic indices were calculated as the proper total and specific peripheral vascular resistance (PTPVR and SPVR), proper minute blood volume and cardiac index (PMBO and CI), indices of cardiac function and vascular tone (ICF and IVT), and the integral indicator of the balance of the cardiac and vascular components (IBCVC). Statistically significant (p<0.05) decreases in TPVR and CTVR and an increase in PTPVR were observed. In the total group (n=66), a positive trend in the CVS functioning was noted in 83.33% of cases.

Conclusion. The use of indices for integrated assessment of the CVS functional state during post-ischemic stroke rehabilitation is relevant and pathogenetically justified. In general, there was a tendency for positive dynamics of CVS functioning and its adaptive potential that confirmed the effectiveness of the rehabilitation activities. The above assessment methods can be proposed for monitoring the effectiveness of rehabilitation in post-stroke patients and for scheduling rehabilitation measured at stage 3.

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Published
30-09-2025
How to Cite
Ivanov K. P. ., Dolgikh V. T. Index assessment of parameters of the cardiovascular system functioning in post-stroke patients // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2025. VOL. 69. № 3. PP. 52–62.
Section
Original research