Мутационная нагрузка митохондриального генома в различных органах и тканях человека

Vasiliy V. Sinyov; Vasiliy P. Karagodin; I. A. Sobenin; A. Yu.; M. A. Sazonova; A. N. Orekhov

Vasiliy V. Sinyov Russian Cardiology Research and Production Complex, Moscow http://orcid.org/0000-0001-5105-5763
Vasiliy P. Karagodin Institute of General Pathology and Pathophysiology http://orcid.org/0000-0003-0501-8499
I. A. Sobenin Russian Cardiology Research and Production Complex; Institute of General Pathology and Pathophysiology http://orcid.org/0000-0003-0978-6444
A. Yu. Russian Cardiology Research and Production Complex, Moscow http://orcid.org/0000-0002-2501-7269
M. A. Sazonova Russian Cardiology Research and Production Complex; Institute of General Pathology and Pathophysiology http://orcid.org/0000-0001-7382-7197
A. N. Orekhov Institute of General Pathology and Pathophysiology, Moscow; Institute for Atherosclerosis Research, Skolkovo Innovative Centre, Moscow http://orcid.org/0000-0002-6495-1628

Keywords: mitochondrial genome; mutation; heteroplasmy level; mutational burden; human organ; human tissue.

Abstract

In the present article the literature data on studies of the heteroplasmy level of human mitochondrial genome in different organs (muscles, liver, kidneys, brain, heart, lungs, hair, small and large bowel, spleen) and tissues (buccal, leukocytes, ruinous epithelial cells) are analyzed. The difference in mutational burden levels of mitochondrial genome between samples of such organs and tissues is shown. Meanwhile, certain regularity was observed in heteroplasmy level distribution of mitochondrial mutations in these samples.

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Mutational burden of mitochondrial genome in different organs and tissues in human

Abstract

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