Pharmacogenetics of drugs in breast cancer and new approaches for improvement of their bioavailability

  • Alexey M. Burdennyy Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow 125315, Russia; Institute for Biochemical Physics, Kosygina Str. 4, Moscow 119334, Russia http://orcid.org/0000-0002-9398-8075
  • S. S. Lukina I.M. Sechenov First Moscow State Medical University, Trubetskaya Str. 8, Moscow 119991, Russia
  • T. M. Zavarykina Institute for Biochemical Physics, Kosygina Str. 4, Moscow 119334, Russia
  • I. V. Pronina Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow 125315, Russia
  • P. K. Brenner Institute for Biochemical Physics, Kosygina Str. 4, Moscow 119334, Russia; K.I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology, Academika Skryabina Str. 23, Moscow 109472, Russia
  • M. A. Kapralova Institute for Biochemical Physics, Kosygina Str. 4, Moscow 119334, Russia; K.I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology, Academika Skryabina Str. 23, Moscow 109472, Russia
  • M. V. Atkarskaya Institute for Biochemical Physics, Kosygina Str. 4, Moscow 119334, Russia
  • E. A. Filippova Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow 125315, Russia
  • N. A. Ivanova Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow 125315, Russia
  • M. P. Kruglova I.M. Sechenov First Moscow State Medical University, Trubetskaya Str. 8, Moscow 119991, Russia
  • M. V. Belova I.M. Sechenov First Moscow State Medical University, Trubetskaya Str. 8, Moscow 119991, Russia
  • E. O. Bahrushina I.M. Sechenov First Moscow State Medical University, Trubetskaya Str. 8, Moscow 119991, Russia
  • E. A. Braga Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow 125315, Russia; Research Centre for Medical Genetics, Moskvorechje Str. 1, Moscow 115522, Russia
  • V. I. Loginov Institute of General Pathology and Pathophysiology, Baltiyskaya Str. 8, Moscow 125315, Russia; Research Centre for Medical Genetics, Moskvorechje Str. 1, Moscow 115522, Russia http://orcid.org/0000-0003-2668-8096
DOI: https://doi.org/10.25557/0031-2991.2019.04.137-150
Keywords: breast cancer, pharmacogenetics, efflux transporters, drug targets, personalized therapy

Abstract

This review analyzed Russian and international studies focusing on the pharmacogenetic approach to treatment of breast cancer. Also, the authors presented results of clinical studies, which showed the role of molecular genetic markers in the efficacy of breast cancer therapy. Allelic variants of different genes have been shown to exert different influences on drug effects. Both inherited and somatic changes in the patient’s genome are pharmacogenetically significant. Inherited genetic variants are generally used for evaluating efficacy and toxicity of drugs while somatic mutations and other known changes in tumor cells are used primarily for selection of treatment and creation of a base for enhancing the effectiveness of therapy. A promising and rapidly developing field of modern pharmacology is targeted delivery of drugs to the tumor. This review summarized state-of-the-art knowledge of new developments in transport of drugs to tumor tissue.

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Published
2019-11-14
How to Cite
Burdennyy A. M., Lukina S. S., Zavarykina T. M., Pronina I. V., Brenner P. K., Kapralova M. A., Atkarskaya M. V., Filippova E. A., Ivanova N. A., Kruglova M. P., Belova M. V., Bahrushina E. O., Braga E. A., Loginov V. I. Pharmacogenetics of drugs in breast cancer and new approaches for improvement of their bioavailability // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2019. VOL. 63. № 4. PP. 137–150.
Issue
Vol. 63 No. 4 (2019)
Section
Reviews

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