Hyperhomocysteinemia and chronic kidney disease

  • Maria P. Kruglova FSAEI HE I.М. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 119991 Moscow, Trubetskaya Str. 8, Bld. 2 http://orcid.org/0000-0001-6939-160X
  • A. V. Ivanov FSBSI «Institute of General Pathology and Pathophisiology», 125315 Moscow, Baltiyskaya Str. 8 http://orcid.org/0000-0002-2424-6115
  • O. Yu. Vvedenskaya FSAEI HE I.М. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 119991 Moscow, Trubetskaya Str. 8, Bld. 2
  • A. A. Kubatiev FSBSI «Institute of General Pathology and Pathophisiology», 125315 Moscow, Baltiyskaya Str. 8 http://orcid.org/0000-0001-8077-2905
DOI: https://doi.org/10.25557/0031-2991.2018.04.195-201
Keywords: Hyperhomocysteinemia, chronic kidney disease, nitrative stress, oxidative stress, gomocysteinilation, hypomethylation, endoplasmic reticulum stress

Abstract

Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular disease and the direct cause of renal injury in patients with chronic kidney disease (CKD). This review considers the potential mechanisms of homocysteine (Hcy) metabolism disorders, and pathogenesis of molecular and cellular damage mediated by hyperhomocysteinemia (ННсу).

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Published
2018-11-21
How to Cite
Kruglova M. P., Ivanov A. V., Vvedenskaya O. Y., Kubatiev A. A. Hyperhomocysteinemia and chronic kidney disease // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2018. VOL. 62. № 4. PP. 195–201.
Issue
Vol. 62 No. 4 (2018)
Section
Reviews