Changes in corticosterone levels and enzyme activities of thyroid hormone liberin metabolism in rats during cold swimming stress

Abstract

Cold, being one of the most powerful stressors, activates the sympathoadrenal system, increasing the release of the pituitary thyroid-stimulating hormone, the level of which is regulated by its hypothalamic releasing factor (TRH). Glucocorticoids affect the brain content of TRH, the level of which in the hypothalamus changes after a short-term exposure to cold, and then returns to its original values, indicating the activation in the cells of the adrenal cortex of the transcription of neurohormones involved in the regulation of the thyroid axis. At the same time, changes in the activity of enzymes of its metabolism are possible. In modern conditions, a person is exposed to various stressful situations, leading to changes in the level of a number of hormones, including glucocorticoids, catecholamines, growth hormone, prolactin. Under stress, there are changes in the hypothalamic-pituitary-adrenocortical and other neuroendocrine systems, often leading to endocrine disorders. Central role in the formation and implementation of stress