Influence of the nitric oxide donors on the microcirculation in infusion therapy of the experimental hemorrhagic shock

  • M. I. Remizova Russian Research Institute of Hematology and Transfusiology, St-Petersburg, Russia
  • K. A. Gerbout Russian Research Institute of Hematology and Transfusiology, St-Petersburg, Russia
  • G. V. Grishina Russian Research Institute of Hematology and Transfusiology, St-Petersburg, Russia
  • K. N. Nagornaya Russian Research Institute of Hematology and Transfusiology, St-Petersburg, Russia
Keywords: hemorrhagic shock, infusion therapy, rats, blood circulation, nitric oxide, L-Arginine, Oxacom

Abstract

Infusion of the nitric oxide donors L-Arginine (150 mg/kg bolus) and Oxacom (3,2 mM/ kg bolus) with saline solution has been shown improves cardiovascular and metabolic changes in animal model of hemorrhagic shock. As a result improves survival rats. These data made this effect clinically attractive.

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Published
2014-12-05
How to Cite
Remizova M. I., Gerbout K. A., Grishina G. V., Nagornaya K. N. Influence of the nitric oxide donors on the microcirculation in infusion therapy of the experimental hemorrhagic shock // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2014. VOL. 58. № 4. PP. 91–95.
Issue
Vol. 58 No. 4 (2014)
Section
Original research