The changes in the biochemical indices of blood in cobalt intoxication on the background of the regulators of the expression of endothelial NO-synthase

  • S. G. Dzugkoev Institute of Biomedical Research, Vladikavkaz, Russian Federation
  • I. V. Mozhayeva Institute of Biomedical Research, Vladikavkaz, Russian Federation
  • L. B. Gigolaeva North Ossetian State Medical Academy, Vladikavkaz, Russian Federation
  • A. I. Tedtoeva Institute of Biomedical Research, Vladikavkaz, Russian Federation
  • O. I. Margieva Institute of Biomedical Research, Vladikavkaz, Russian Federation
  • F. S. Dzugkoeva Institute of Biomedical Research, Vladikavkaz, Russian Federation
Keywords: oxidative stress, nitric oxide, cobalt chloride, L-arginine, L-NAME, NOS-3

Abstract

On the background of chronic cobalt intoxication in rats develops oxidative stress. This is accompanied by a decrease in the content of total metabolites of nitric oxide in the blood serum. The reasons for lower levels of the vasodilatation factor are the following: a deficiency of L-arginine and the increase in the content of the inhibitor of NOS-3. We found a decrease in the bioavailability of nitric oxide due to the increase in the content of oxidized low density lipids, total cholesterol and cholesterol-lowering lipids high density.

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Published
2014-12-05
How to Cite
Dzugkoev S. G., Mozhayeva I. V., Gigolaeva L. B., Tedtoeva A. I., Margieva O. I., Dzugkoeva F. S. The changes in the biochemical indices of blood in cobalt intoxication on the background of the regulators of the expression of endothelial NO-synthase // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2014. VOL. 58. № 4. PP. 66–70.
Issue
Vol. 58 No. 4 (2014)
Section
Original research