Agonists of 5HT2C-receptors SCH 23390 and MK 212 incresase the force of rat aorta contraction in the presence of vasopressin and angiotensin II

  • L. M. Kozhevnikova Institute of General Pathology and Pathophysiology, Moscow, Russia
  • M. V. Mesitov Institute of General Pathology and Pathophysiology, Moscow, Russia
  • A. A. Moskovtsev Institute of General Pathology and Pathophysiology, Moscow, Russia
  • Institute of General Pathology and Pathophysiology, Moscow, Russia
Keywords: serotonin, 5НТ2С receptors, SCH 23390 and МК 212 agonists, mRNA expression, vasoconstriction, calmodulin, c-Src kinase

Abstract

We investigated the role of 5НТ2С receptors in regulation of blood vessel contractility. We determined expression of 5НТ2С receptors in smooth muscle cell line A7r5 as well as on isolated rat aorta. It was shown that strong vasoconstriction effect of 5НТ2С receptor agonists — SCH 23390 and МК 212 appeared on blood vessels after preliminary activation of angiotensin AT1A- and vasopressin V1A-receptors. Biphasic contraction (a rhythmic alternation of contraction and subsequent relaxation phases of aortic rings) and tonic contraction were observed in 75% and 25% of the cases after 5НТ2С receptor activation, respectively. Periodic high amplitude constrictions of isolated rat aorta, induced by SCH 23390 and МК 212 agonists, were persisted for a long time (>

Downloads

Download data is not yet available.
Published
2014-12-05
How to Cite
Kozhevnikova L. M., Mesitov M. V., Moskovtsev A. A., . Agonists of 5HT2C-receptors SCH 23390 and MK 212 incresase the force of rat aorta contraction in the presence of vasopressin and angiotensin II // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2014. VOL. 58. № 4. PP. 17–29.
Issue
Vol. 58 No. 4 (2014)
Section
Original research