Molecular mechanisms of modulation of lipolysis in adipose tissue and development of insulinresistance in diabetes

  • V. V. Ivanov Siberian state medical university, Tomk, Russia
  • E. V. Shakhristova Siberian state medical university, Tomk, Russia
  • E. A. Stepovaya Siberian state medical university, Tomk, Russia
  • О. L. Nosareva Siberian state medical university, Tomk, Russia
  • T. S. Fedorova Siberian state medical university, Tomk, Russia
  • Siberian state medical university, Tomk, Russia
Keywords: diabetes mellitus, adipocyte, oxidative stress, oxidative modification of proteins, lipid peroxidation, alloxan

Abstract

Analysis of modern literature data as well as the results of personal research on development of oxidative stress in adipose tissue in diabetes is presented. Mechanisms of modulation of spontaneous and induced lipolysis in adipocytes in conditions of oxidative stress are discussed. Participation of adipose tissue in forming insulin resistance in types 1 and 2 diabetes is considered.

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Published
2014-12-05
How to Cite
Ivanov V. V., Shakhristova E. V., Stepovaya E. A., Nosareva О. L., Fedorova T. S., . Molecular mechanisms of modulation of lipolysis in adipose tissue and development of insulinresistance in diabetes // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2014. VOL. 58. № 4. PP. 111–119.
Issue
Vol. 58 No. 4 (2014)
Section
Reviews