Possibility of diagnostics of the non-steroidal anti-inflammatory drugs intolerance with a change in the chemiluminescent glow of the polymorphonuclear leukocytes of the peripheral blood

  • S. V. Chausova Russian National Research Medical University, Moscow, Russia
  • K. G. Gurevich Moscow State Medical and Dental University, Moscow, Russia
  • G. P. Bondareva Institute of Immunology, Moscow, Russia
  • O. Ju. Filatov Moscow State Medical and Dental University, Moscow, Russia
  • I. Y. Malyshev Moscow State Medical and Dental University, Moscow, Russia; Institute of General Pathology and Pathophysiology, Moscow, Russia
Keywords: chemiluminescence, non-steroidal anti-inflammatory drugs intolerance, sodium salicylate, sodium metamizol, sodium diclofenac

Abstract

We investigated the intensity of barium sulfate stimulated luminol-dependent chemiluminescence (SLCL) of pre-incubated blood with various concentrations of sodium salicylate, sodium metamizol or sodium diclofenac. Blood was received from healthy donors and patients with intolerance to aspirin and / or sodium metamizol and / or sodium diclofenac. Revealed valid differences in SLCL of blood received from healthy donors and patients with intolerance to these drugs allows us to use chemiluminescence method for the diagnosis of intolerance to non-steroidal anti-inflammatory drugs.

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Published
05-12-2014
How to Cite
Chausova S. V., Gurevich K. G., Bondareva G. P., Filatov O. J., Malyshev I. Y. Possibility of diagnostics of the non-steroidal anti-inflammatory drugs intolerance with a change in the chemiluminescent glow of the polymorphonuclear leukocytes of the peripheral blood // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2014. VOL. 58. № 4. PP. 127–132.
Issue
Vol. 58 No. 4 (2014)
Section
Methods