The endothelium of the vessels and proxidative-antioxidative balans in pregnancy rats with endothoxinaemia

Abstract

Actual problem of modern obstetrics is the infection in pregnancy which leads the deadborn, early children`s death rate and disease. In Belarus disease of newborns at specific infections for postnatal the period has made 14,1‰, and death rate of 0,38‰. The purpose of researches — to study a condition endothelium and activity of lipid peroxidation products at pregnant rats with endothoxinaemia. In experiments on 49 pregnancy rats with intramuscular introduction of endotoxine (Lipopolysaccharide E. сoli Serotype О127:В8 «Sigma») during the period placentation dysfunction development endothelium is established, that was shown more expressed in 2,3 times (p<0,05) constriction by reaction on noradrenalin, increase in 18,3 times (p<0,001) quantities circulating endothelium cages and decrease in 14 times (p <0,001) the dependent endothelium vasodilatation under influence acetilcholine, to the dress increase of level of lipid peroxidation products: concentration of diene conjugates ов on 91% (p <0,001), malone dialdegide — on 56% (p <0,001), Shiff bases — on 7,9% (p <0,05); and decrease in indicators of antioxidant protection: maintenances retinol on 29% (p <0,05), a-tocopherol — on 6% (p<0,001).