Dynamics of changes of р53-positive cells morphofunctional condition in the cerebral cortex of the temporal lobe in rats affected by carotid ischemia-reperfusion

Abstract

The influence of bilateral 20-minute carotid ischemia with reperfusion of various duration upon the activity of apoptotic processes in the neurons and glia cells of the cerebral cortex in the temporal lobe of rats has been studied. Bilateral carotid ischemia with one-hour reperfusion has been indicated to increase the location density of р53+-neurocytes in this region of the cerebral cortex, increases percentage and density of р53+-nerve cells and reduces the percentage and density of р53+-glia cells on the 12th day of the post-ischemic period. Ischemic-reperfusion lesion of the brain increases the concentration of р53 protein in glia cells of the cerebral cortex in the temporal region in the early ischemic-reperfusion period and reduces it in nerve and glia cells in the late one.