Effect of L-carnitine, afobazole and their combination with L-arginine on biochemical and histological indices of endothelial disfunction in cobalt intoxication in rats

  • S. G. Dzugkoev ERAS Institute of Biomedical Research of RAS VSC, department of pathobiochemistry, Vladikavkaz, Russia
  • I. V. Mozhaeva ERAS Institute of Biomedical Research of RAS VSC, department of pathobiochemistry, Vladikavkaz, Russia
  • M. A. Otiev ERAS Institute of Biomedical Research of RAS VSC, department of pathobiochemistry, Vladikavkaz, Russia
  • O. I. Margieva ERAS Institute of Biomedical Research of RAS VSC, department of pathobiochemistry, Vladikavkaz, Russia
  • F. S. Dzugkoeva ERAS Institute of Biomedical Research of RAS VSC, department of pathobiochemistry, Vladikavkaz, Russia
Keywords: lipid peroxidation, antioxidant system, nitric oxide, regulators of expression of eNOS, histology, afobazole, L-carnitine

Abstract

The influence of L-carnitine and afobazole and their combination with L-arginine on biochemical and histological indices of endothelial dysfunction in rats with cobalt intoxication. The obtained data revealed biochemical markers of endothelial dysfunction. Found that in rats with cobalt intoxication during treatment occurred inhibition of lipid peroxidation (LPO), reduced the concentration of malondialdehyde (MDA) in erythrocytes, activation of superoxide dismutase (SOD). This was accompanied by increased concentrations of nitric oxide (NO), the availability of the substrate L-arginine and possibly the expression of eNOS in the background of L-carnitine and afobazole.

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Published
2015-07-09
How to Cite
Dzugkoev S. G., Mozhaeva I. V., Otiev M. A., Margieva O. I., Dzugkoeva F. S. Effect of L-carnitine, afobazole and their combination with L-arginine on biochemical and histological indices of endothelial disfunction in cobalt intoxication in rats // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2015. VOL. 59. № 2. PP. 70–75.
Issue
Vol. 59 No. 2 (2015)
Section
Original research