Functional facets of dopaminergic system and cancer. Part 2

Abstract

Stress as a modern civilization factor significantly affects our lives. While acute stress might have positive effect on the organism, chronic stress is usually detrimental and might lead to serious health complications as well as cancer considered to be age-disease. It is also known that stress can significantly impair the efficacy of cytotoxic chemotherapies and anti-tumour immune response, up-regulate tumour growth and metastasis spreading. Meanwhile dopamin known to be antiaging and antistress agent is able to down-regulate tumourgenesis. Therefore central neuronal that is dopaminergic system complicity in stress control mechanisms of tumour development we discuss in the review.