Система мозгового нейротрофического фактора (BDNF) как мишень для создания лекарственных средств, восстанавливающих иннервацию

Dmitriy V. Stambolsky; O. S. Plekhanova; I. Yu. Yudina; N. I. Kalinina; M. N. Karagyaur; V. E. Dubrov; A. Yu. Kochish; E. V. Semina; Zh. A. Akopyan; I. O. Golubev; A. V. Antonov; Sh. M. Safin; V. A. Tkachuk

doi:10.25557/IGPP.2017.4.8534

Dmitriy V. Stambolsky Department of Basic Medicine, M.V. Lomonosov Moscow State University, Moscow, Russia http://orcid.org/0000-0001-6983-9697
O. S. Plekhanova Department of Basic Medicine, M.V. Lomonosov Moscow State University, Moscow, Russia http://orcid.org/0000-0002-4693-295X
I. Yu. Yudina I.M. Sechenov First Moscow State Medical University, Moscow, Russia http://orcid.org/0000-0002-4138-6371
N. I. Kalinina Department of Basic Medicine, M.V. Lomonosov Moscow State University, Moscow, Russia http://orcid.org/0000-0003-3497-9619
M. N. Karagyaur Medical Research and Education Center of Lomonosov Moscow State University, Moscow, Russia http://orcid.org/0000-0003-4289-3428
V. E. Dubrov Department of Basic Medicine, M.V. Lomonosov Moscow State University, Moscow, Russia http://orcid.org/0000-0001-5929-8225
A. Yu. Kochish P.P. Vreden Russian Research Institute of Traumatology and Orthopedics, St. Petersburg, Russia http://orcid.org/0000-0002-2466-7120
E. V. Semina Department of Basic Medicine, M.V. Lomonosov Moscow State University, Moscow, Russia; Russian Cardiology Research Center, Moscow, Russia http://orcid.org/0000-0002-3927-9286
Zh. A. Akopyan Department of Basic Medicine, M.V. Lomonosov Moscow State University, Moscow, Russia; Medical Research and Education Center of Lomonosov Moscow State University, Moscow, Russia http://orcid.org/0000-0002-0989-7825
I. O. Golubev N.N. Priorov Central Research Institute of Traumatology and Orthopedics, Moscow, Russia http://orcid.org/0000-0002-1291-5094
A. V. Antonov G.G. Kuvatov Bashkortostan Republican Clinical Hospital, Ufa, Bashkortostan http://orcid.org/0000-0001-7385-5331
Sh. M. Safin G.G. Kuvatov Bashkortostan Republican Clinical Hospital, Ufa, Bashkortostan http://orcid.org/0000-0002-0100-6100
V. A. Tkachuk Department of Basic Medicine, M.V. Lomonosov Moscow State University, Moscow, Russia; Russian Cardiology Research Center, Moscow, Russia http://orcid.org/0000-0002-7492-747X

DOI: https://doi.org/10.25557/IGPP.2017.4.8534

Keywords: brain-derived neurotrophic factor, innervation, nerve regeneration

Abstract

Brain-derived neurotrophic factor (BDNF) is a major neurotrophic factor maintaining the nervous system function and regeneration. Based on reports indicating that BDNF enhances neuronal regeneration, in recent years, BDNF has been considered a promising therapeutic target. The aim of this review was to summarize current data on BDNF expression, signaling, and mechanisms for stimulation of reinnervation. Conclusion. Recent studies of the role of BDNF showed that continuation of research and development of BDNF-based drugs stimulating regeneration of nervous system components is advisable and promising.

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The brain-derived neurotrophic factor (BDNF) system as a therapeutical target for development of drugs restoring innervation

Abstract

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