Comparison of neuroprotective effects of derivatives of eritropoetine by different way of bringing in drugs with model of bilateral photochemically induced thrombosis of the prefrontal cortex of rat brain

  • F. M. Shakova Sientific Research Institute of General Pathology and Pathophisiology
  • T. I. Kalinina State Research Institute of Genetics and Selection of Industrial Microorganisms
  • I. V. Barskov Sientific Center of Neurology
  • E. V. Stelmashuk Sientific Center of Neurology
  • E. E. Genrixc State Research Institute of Genetics and Selection of Industrial Microorganisms
  • V. L. Yrin Sientific Research Institute of General Pathology and Pathophisiology
  • G. A. Romanova Sientific Research Institute of General Pathology and Pathophisiology
Keywords: photothrombosis, prefrontal cortex, derivatives of eritropoetine: Epo Epo-Fc Epo-Tr, neuroprotective and antiamnestic action, intranasal and intraperitoneal injection

Abstract

It was stated with model of bilateral photochemically induced thrombosis of the prefrontal cortex by injected intranasally or intraperitoneally in 1h after operation new derivatives of eritropoetine : Epo, Epo-Fc, Epo-Tr provoked neuroprotective and antiamnestic action. Epo-Fc demonstrated more effective action by intranasal injection.

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Published
2015-11-11
How to Cite
Shakova F. M., Kalinina T. I., Barskov I. V., Stelmashuk E. V., Genrixc E. E., Yrin V. L., Romanova G. A. Comparison of neuroprotective effects of derivatives of eritropoetine by different way of bringing in drugs with model of bilateral photochemically induced thrombosis of the prefrontal cortex of rat brain // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2015. VOL. 59. № 3. PP. 28–33.
Issue
Vol. 59 No. 3 (2015)
Section
Original research