Expression of vascular endothelial growth factor (VEGF) in uterine tissues as one of the mechanisms of algogenezis in adenomyosis, associated with chronic pelvic pain

Abstract

Objective: to study the expression of VEGF in the uterus tissue in patients with adenomyosis associated with chronic pelvic pain. Methods. For morphological studies it were using fragments of walls 60 uterus, received after hysterectomy in patients with pelvic pain on a background of diffuse adenomyosis II-III degree, and 30 uterus of women with painless form of adenomyosis. Expression of vascular endothelial growth factor (VEGF) was measured in endometrial and myometrial tissues using immunohistochemistry. The results showed a significantly higher expression of VEGF in patients with adenomyosis pain phenotype compared to the same in women with silent form in the epithelial cells of ectopic endometrium (14,7±1,6 vs. 10,7±1,6%, p<0,01) in the smooth muscle cells of the myometrium (12,6±1,4 vs. 9,6±1,2%, p<0,01), in the stromal cells of the myometrium (10,1±1,9 vs. 7,4±1,8%, p <0,01). Conclusions: The increased expression of VEGF in the uterus with adenomyosis tissues, associated with chronic pelvic pain, compared to the pain-free phenotype of the disease is one of the most important pathogenetic mechanism of algogenezis in adenomyosis and the formation of a painful disease phenotype.