Hemoglobin oxygen transport capacity in surgical endotoxicosis

  • G. V. Poryadin In surgical endointoxication hemoglobin oxygen transport capacity of red blood cells (hemoglobin affinity ligands: the ability to bind and release ligands) is reduced and is associated with the severity of endogenous intoxication. Violation of oxygen transport function of hemoglobin at endogenous intoxication is associated with conformational changes of a biomolecule, and its possible influence on reactive oxygen species, which confirmed in experiments in vitro: under the influence of oxygen-iron ascorbate ability of hemoglobin deteriorates. Largely similar structural and functional changes in hemoglobin occur in patients with surgical endotoxicosis.
  • А. P. Vlasov Keywords: red blood cells, hemoglobin, Raman scattering, lipid peroxidation, endotoxemia.
  • V. A. Trofimov Keywords: red blood cells, hemoglobin, Raman scattering, lipid peroxidation, endotoxemia.
  • T. I. Vlasova Keywords: red blood cells, hemoglobin, Raman scattering, lipid peroxidation, endotoxemia.
  • O. V. Kamkina In surgical endointoxication hemoglobin oxygen transport capacity of red blood cells (hemoglobin affinity ligands: the ability to bind and release ligands) is reduced and is associated with the severity of endogenous intoxication. Violation of oxygen transport function of hemoglobin at endogenous intoxication is associated with conformational changes of a biomolecule, and its possible influence on reactive oxygen species, which confirmed in experiments in vitro: under the influence of oxygen-iron ascorbate ability of hemoglobin deteriorates. Largely similar structural and functional changes in hemoglobin occur in patients with surgical endotoxicosis.
  • A. G. Grigoryev Keywords: red blood cells, hemoglobin, Raman scattering, lipid peroxidation, endotoxemia.
  • P. А. Vlasov Keywords: red blood cells, hemoglobin, Raman scattering, lipid peroxidation, endotoxemia.
Keywords: б авторах

Abstract

For correspondence: Vlasov А.P., e-mail: vap.61@yandex.ruConflict of interest. The authors declare no conflict of interest.

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Published
2016-03-22
How to Cite
Poryadin G. V., Vlasov А. P., Trofimov V. A., Vlasova T. I., Kamkina O. V., Grigoryev A. G., Vlasov P. А. Hemoglobin oxygen transport capacity in surgical endotoxicosis // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2016. VOL. 60. № 1. PP. 23–27.
Issue
Vol. 60 No. 1 (2016)
Section
Original research