Влияние посткондиционирования сердца на некроз, апоптоз, онкоз и аутофагию кардиомиоцитов

Leonid N. Maslov; N. V. Naryzhnaya; A. S. Sementsov; A. V. Mukhomedzyanov; A. S. Gorbunov

Impact of postconditioning of the heart on necrosis, apoptosis, oncosis, autophagy of cardiomyocytes

Leonid N. Maslov Research Institute of Cardiology, Tomsk, Russia http://orcid.org/0000-0002-6020-1598
N. V. Naryzhnaya Research Institute of Cardiology, Tomsk, Russia http://orcid.org/0000-0003-2264-1928
A. S. Sementsov Research Institute of Cardiology, Tomsk, Russia http://orcid.org/0000-0002-6991-4930
A. V. Mukhomedzyanov Research Institute of Cardiology, Tomsk, Russia http://orcid.org/0000-0003-1808-556X
A. S. Gorbunov Research Institute of Cardiology, Tomsk, Russia ttp://orcid.org/ 0000-0002-5890-071X

Keywords: heart, postconditioning, necrosis, apoptosis, oncosis, autophagy

Abstract

Postconditioning limits cardiomyocyte necrosis induced by reperfusion. Antinecrotic effect postconditioning is limited by strict time limits and depends on the duration of ischemia postconditioning protocol used. The most of the publications shows that postconditioning inhibits apoptosis of cardiomyocytes evoked by reperfusion. There is evidence that postconditioning prevents reoxygenation oncosis of cardiac cells and enhances autophagy of cardiomyocytes.

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Published

2016-05-27

How to Cite

Maslov L. N., Naryzhnaya N. V., Sementsov A. S., Mukhomedzyanov A. V., Gorbunov A. S. Impact of postconditioning of the heart on necrosis, apoptosis, oncosis, autophagy of cardiomyocytes // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2016. VOL. 60. № 2. PP. 94–100.

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Issue

Vol. 60 No. 2 (2016)

Section

Reviews