Subpopulation structure of T-regulatory cells and proliferative response of blood lymphocytes in vitro under pulmonary tuberculosis

  • Yelena G. Churina Siberian State Medical University, Tomsk, Russia
  • Vyacheslav V. Novitsky Siberian State Medical University, Tomsk, Russia
  • Olga I. Urazova Siberian State Medical University, Tomsk, Russia
  • Olga V. Voronkova Siberian State Medical University, Tomsk, Russia
  • Irina O. Naslednikova Siberian State Medical University, Tomsk, Russia
  • Olga V. Filinjuk Siberian State Medical University, Tomsk, Russia
Keywords: pulmonary tuberculosis, T-regulatory cells, lymphocytes proliferative activity

Abstract

Subpopulation structure of T-regulatory cells and proliferative activity of blood lymphocytes in vitro in patients with different clinical forms of pulmonary tuberculosis were studied in this work. It has been shown that Trn — natural T-regulatory lymphocytes (CD4+CD25+Foxp3+) play a leading role in formation of immunesuppression under infiltrative, disseminated and fibrosis-cavernous pulmonary tuberculosis. Besides, their number is increased in blood of both tuberculin-positive and tuberculin-negative patients. Negative correlation between the number of Trn and proliferative activity of blood lymphocytes (basal, mitogen- and antigen-induced) has been established, which testifies about participation of Trn in suppression of lymphocyte proliferation and Th1- and Th2-immune response.

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Published
2012-03-12
How to Cite
Churina Y. G., Novitsky V. V., Urazova O. I., Voronkova O. V., Naslednikova I. O., Filinjuk O. V. Subpopulation structure of T-regulatory cells and proliferative response of blood lymphocytes in vitro under pulmonary tuberculosis // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2012. VOL. 56. № 1. PP. 13–18.
Issue
Vol. 56 No. 1 (2012)
Section
Original research

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