Clinical efficacy of the polypeptide drug Cortexin in the treatment of circulatory and post-traumatic disorders
Keywords:
cerebral ischemia, cognitive skills, Cortexin, peptide drugs, posttraumatic disorders
Abstract
Pathological brain remodeling is one of the most dangerous risk factors that threatens a person's full-quality life due to the dysregulation of other body systems and direct impact on thinking, psychosomatic and analytical functions. Taking into account the special risk of central lesions for both biological and social activities of the patient, many Russian and international specialists are looking for new opportunities to improve both medical and surgical correction for cerebral disorders. This review summarizes major studies that convincingly demonstrated the effectiveness of including the polypeptide drug Cortexin into the complex therapy of post-traumatic and circulatory disorders to regenerate and improve cerebral tissue perfusion and restore cognitive skills of patients. The analysis of clinical studies of Cortexin revealed the composition of the evidence base for the extensive use of this peptide drug in various fields of medicine.
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References
1. Khavinson V. H. Drug peptide preparations: past, present, future //Clinical Medicine. - 2020. - Т. 98. - №. 3. -
С. 165-177.
2. Polyansky M. A., Ginak A. I. Basic concepts of peptide synthesis as a new generation of biologically active drugs // Proceedings of St. Petersburg State Technological Institute (Technical University). - 2021. - №. 58. - С. 62-65.
3. Korotayeva E. O. Nootropic drugs of peptide nature, standardization and quality control //BBK 53.5+ 54.1 P 44. - 2020. - С. 181. Korotaeva E. O. Nootropic drugs of peptide nature, standardization and quality control //BBK 53.5+ 54.1 P 44. - 2020. - С. 181.
4. Koshmanova, A. N. Prospects for the use of Cortexin // Glavvrach. - 2022. - № 7. - С. 21-24.
5. Yakovlev, A. A. et al. The peptide drug cortexin inhibits brain caspase-8 // Biomedical Chemistry. - 2017. - Т. 63. - №. 1. - С. 27-31.
6. Sinyavskiy V. V. Optimization of methods of correction and prevention of cognitive disorders in patients with posttraumatic epilepsy //Consilium Medicum. - 2020. - Т. 22. - №. 9. - С. 23-27.
7. Studenikin V. M. et al. Application of Cortexin in neurology: from perinatal to gerontological pathology //Vestnik of the Russian Military Medical Academy. - 2010. - №. 3. - С. 246-249.
8. Mamenkova A. S. Neuroprotective therapy for chronic cerebral ischemia (literature review) // Bulletin of the Northern State Medical University. - Ar. - 2021. - С. 40.
9. Studenikin V. M. et al. Peptide neuroprotection in pediatric neuropharmacology: from correction of developmental delays to acute cerebral circulation disorders //Effective Pharmacotherapy. - 2012. - №. 13. - С. 16-21.
10. Dyakonov M. M., Shabanov P. D. To the question of the neuroprotective effect of peptide drugs // Herald of the Russian Military Medical Academy. - 2011. - №. 1. - С. 255-258.
11. Tsygan V.N. Electroencephalography / V. N. Tsygan, M.M. Bogoslovsky, A.V. Mirolyubov; eds. N. Tsygan, M. M. Bogoslovsky, A. V. Mirolyubov; ed. by M. M. Dyakonov. M. M. Dyakonov. - SPb.: “Nauka, 2008. - 192 p., ill.
12. Tanashyan M. M., Konovalov R. N., Lagoda O. V. New approaches to the correction of cognitive impairment in cerebrovascular diseases // Annals of Clinical and Experimental Neurology. - 2018. - Т. 12. - №. 3. - С. 30-39.
13. Prokaeva T. A. et al. Cortexin in the prevention of intracranial hypertension syndrome in the consequences of closed craniocerebral trauma //Acta Biomedica Scientifica. - 2012. - №. 6 (88). - С. 33-35.
14. Arlt A. V. Effects of cortexin, valsartan, perindopril
and ramipril on changes in cerebral blood flow volume velocity.
in the postischemic period // International Research Journal. - 2022. - №. 11 (125). - С. 64.
15. Tsygan V. N. Chronic fatigue syndrome and its correction with Cortexin // RMZh. - 2010. - Т. 18. - №. 16. - С. 1004-1007.
16. Kolesnikova E. V. et al. Experience in the use of Cortexin for the correction of cognitive impairment in children with cerebral palsy //Medical prevention, rehabilitation and spa medicine at the turn of the III millennium: a collection of articles of the international scientific and practical conference. - 2016. - С. 27.
17. Plavinsky S. L., Shabalkin P. I. Meta-analysis. Cerebrolysin, Cortexin, Cellex: effectiveness in vascular dementia, Alzheimer's disease and ischemic stroke //Medicine. - 2016. - Т. 4. - №. 2. - С. 1-15.
18. Reutov V. P. et al. Cortexin and nitrite in combination with Cortexin reduce edema and destruction of cerebellar neurons in hemorrhagic stroke // Reports of the Academy of Sciences. - Federal State Budgetary Institution “Russian Academy of Sciences”, 2009. - Т. 426. - №. 3. - С. 410-413.
19. Lysova E. A. Complex cognitive rehabilitation of elderly patients with metabolic syndrome: dis. - 2021.
16. Kolesnikova E. V. et al. Experience in the use of Cortexin for the correction of cognitive impairment in children with cerebral palsy //Medical prevention, rehabilitation and spa medicine at the turn of the III millennium: a collection of articles of the international scientific and practical conference. - 2016. - С. 27.
17. Plavinsky S. L., Shabalkin P. I. Meta-analysis. Cerebrolysin, Cortexin, Cellex: effectiveness in vascular dementia, Alzheimer's disease and ischemic stroke //Medicine. - 2016. - Т. 4. - №. 2. - С. 1-15.
18. Reutov V. P. et al. Cortexin and nitrite in combination with Cortexin reduce edema and destruction of cerebellar neurons in hemorrhagic stroke // Reports of the Academy of Sciences. - Federal State Budgetary Institution “Russian Academy of Sciences”, 2009. - Т. 426. - №. 3. - С. 410-413.
19. Lysova E. A. Complex cognitive rehabilitation of elderly patients with metabolic syndrome: dis. - 2021.
С. 165-177.
2. Polyansky M. A., Ginak A. I. Basic concepts of peptide synthesis as a new generation of biologically active drugs // Proceedings of St. Petersburg State Technological Institute (Technical University). - 2021. - №. 58. - С. 62-65.
3. Korotayeva E. O. Nootropic drugs of peptide nature, standardization and quality control //BBK 53.5+ 54.1 P 44. - 2020. - С. 181. Korotaeva E. O. Nootropic drugs of peptide nature, standardization and quality control //BBK 53.5+ 54.1 P 44. - 2020. - С. 181.
4. Koshmanova, A. N. Prospects for the use of Cortexin // Glavvrach. - 2022. - № 7. - С. 21-24.
5. Yakovlev, A. A. et al. The peptide drug cortexin inhibits brain caspase-8 // Biomedical Chemistry. - 2017. - Т. 63. - №. 1. - С. 27-31.
6. Sinyavskiy V. V. Optimization of methods of correction and prevention of cognitive disorders in patients with posttraumatic epilepsy //Consilium Medicum. - 2020. - Т. 22. - №. 9. - С. 23-27.
7. Studenikin V. M. et al. Application of Cortexin in neurology: from perinatal to gerontological pathology //Vestnik of the Russian Military Medical Academy. - 2010. - №. 3. - С. 246-249.
8. Mamenkova A. S. Neuroprotective therapy for chronic cerebral ischemia (literature review) // Bulletin of the Northern State Medical University. - Ar. - 2021. - С. 40.
9. Studenikin V. M. et al. Peptide neuroprotection in pediatric neuropharmacology: from correction of developmental delays to acute cerebral circulation disorders //Effective Pharmacotherapy. - 2012. - №. 13. - С. 16-21.
10. Dyakonov M. M., Shabanov P. D. To the question of the neuroprotective effect of peptide drugs // Herald of the Russian Military Medical Academy. - 2011. - №. 1. - С. 255-258.
11. Tsygan V.N. Electroencephalography / V. N. Tsygan, M.M. Bogoslovsky, A.V. Mirolyubov; eds. N. Tsygan, M. M. Bogoslovsky, A. V. Mirolyubov; ed. by M. M. Dyakonov. M. M. Dyakonov. - SPb.: “Nauka, 2008. - 192 p., ill.
12. Tanashyan M. M., Konovalov R. N., Lagoda O. V. New approaches to the correction of cognitive impairment in cerebrovascular diseases // Annals of Clinical and Experimental Neurology. - 2018. - Т. 12. - №. 3. - С. 30-39.
13. Prokaeva T. A. et al. Cortexin in the prevention of intracranial hypertension syndrome in the consequences of closed craniocerebral trauma //Acta Biomedica Scientifica. - 2012. - №. 6 (88). - С. 33-35.
14. Arlt A. V. Effects of cortexin, valsartan, perindopril
and ramipril on changes in cerebral blood flow volume velocity.
in the postischemic period // International Research Journal. - 2022. - №. 11 (125). - С. 64.
15. Tsygan V. N. Chronic fatigue syndrome and its correction with Cortexin // RMZh. - 2010. - Т. 18. - №. 16. - С. 1004-1007.
16. Kolesnikova E. V. et al. Experience in the use of Cortexin for the correction of cognitive impairment in children with cerebral palsy //Medical prevention, rehabilitation and spa medicine at the turn of the III millennium: a collection of articles of the international scientific and practical conference. - 2016. - С. 27.
17. Plavinsky S. L., Shabalkin P. I. Meta-analysis. Cerebrolysin, Cortexin, Cellex: effectiveness in vascular dementia, Alzheimer's disease and ischemic stroke //Medicine. - 2016. - Т. 4. - №. 2. - С. 1-15.
18. Reutov V. P. et al. Cortexin and nitrite in combination with Cortexin reduce edema and destruction of cerebellar neurons in hemorrhagic stroke // Reports of the Academy of Sciences. - Federal State Budgetary Institution “Russian Academy of Sciences”, 2009. - Т. 426. - №. 3. - С. 410-413.
19. Lysova E. A. Complex cognitive rehabilitation of elderly patients with metabolic syndrome: dis. - 2021.
16. Kolesnikova E. V. et al. Experience in the use of Cortexin for the correction of cognitive impairment in children with cerebral palsy //Medical prevention, rehabilitation and spa medicine at the turn of the III millennium: a collection of articles of the international scientific and practical conference. - 2016. - С. 27.
17. Plavinsky S. L., Shabalkin P. I. Meta-analysis. Cerebrolysin, Cortexin, Cellex: effectiveness in vascular dementia, Alzheimer's disease and ischemic stroke //Medicine. - 2016. - Т. 4. - №. 2. - С. 1-15.
18. Reutov V. P. et al. Cortexin and nitrite in combination with Cortexin reduce edema and destruction of cerebellar neurons in hemorrhagic stroke // Reports of the Academy of Sciences. - Federal State Budgetary Institution “Russian Academy of Sciences”, 2009. - Т. 426. - №. 3. - С. 410-413.
19. Lysova E. A. Complex cognitive rehabilitation of elderly patients with metabolic syndrome: dis. - 2021.
Published
2025-03-25
How to Cite
Makeev N. V., Mironov I. V., Antonov M. A., Rudenko D. S. Clinical efficacy of the polypeptide drug Cortexin in the treatment of circulatory and post-traumatic disorders // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2025. VOL. 69. № 1. PP. 111–116.
Issue
Section
Reviews
