Evaluation of serum angiogenesis factors in patients with pelvic venous incompetence
Ангиогенез у женщин с первичным варикозом вен малого таза
Keywords:
pelvic venous incompetence; women; angiogenesis; angiogenesis inhibitors; matrix metalloproteinases; blood serum
Abstract
The issue of angiogenesis (AG) in pelvic venous incompetence (PVI) is not sufficiently covered. A systematic approach to venous dilatation diseases, including from the point of view of AG, will expand the understanding of the pathophysiological mechanisms of PVV and encourage the search for new methods for its correction. Based on the above, the aim of this study was to evaluate the parameters of angiogenesis in women with varying degrees of severity of PVI. We examined 183 patients with PVI, divided according to the severity of the disease into 3 groups: group 1 (mild severity of PVI, n=79); Group 2 (moderate degree, n=63); Group 3 (severe, n=41). Data from 30 apparently healthy women as controls were used. The content of pro- and antiangiogenic factors in peripheral blood plasma was determined by enzyme-linked immunosorbent assay. The results of the study showed the presence of statistically significant differences in patients with stage 1 PVI in terms of higher values of angiogenin, PAI-1, reduced levels of PDGF and TIMP-1 relative to the control. Stage 2 patients had higher concentrations of angiogenin, MMP-8, MMP-9, PAI-1, decreased levels of PDGF and TIMP-1 compared to control values. The third stage of the disease was characterized by increased values of angiogenin, MMP-8, MMP-9, FGF, PAI-1, and decreased levels of PDGF and TIMP-1 compared to control data. These results can contribute to a more accurate assessment of the intensity and dynamics of progression of PVI in women in order to optimize diagnosis and develop correction methods.
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References
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29. Darenskaya M.A., Semendyaev A.A., Stupin D.A., Kolesnikov S.I., Semenova N.V., Pesterev K.V. et al. Pro- and Anti-Inflammatory Blood Cytokines Levels in Women with Moderate and Severe Pelvic Venous Insufficiency. Journal of Biomedicine. 13(1): 54-57. http://dx.doi.org/10.21103/Article13(1)_OA5 I
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2. Barge T.F., Uberoi R. Symptomatic pelvic venous insufficiency: a review of the current controversies in pathophysiology, diagnosis, and management. Clinical Radiology. 2022; 77(6): 409-417. https://doi.org/10.1016/j.crad.2022.01.053
3. Tsukanov Yu.T., Tsukanov A.Yu., Pritykina T.V., Shcheglov V.G., Mozgovoy S.I. Biochemical, immunological and pathomorphological features of varicose veins in patients with undifferentiated connective tissue dysplasia. Kazanskiy meditsinskiy zhurnal. 2007; 88(S5): 132-137. (In Russian)
4. Bałabuszek K., Toborek M., Pietura R. Comprehensive overview of the venous disorder known as pelvic congestion syndrome. Annals of Medicine. 2022; 54(1): 22-36. https://doi.org/10.1080/07853890.2021.2014556
5. Kolesnikova L.I., Semendyaev A.A., Stupin D.A., Darenskaya M.A., Grebenkina L.A., Natyaganova L.V. et al. The intensity of lipid peroxidation processes in women with primary varicose veins of the small pelvis, depending on the stage of the disease. Vestnik Rossiyskoy AMN. 2018; 73(4): 229-235. (In Russian) https://doi.org/10.15690/vramn1005
6. Yetkin E., Ileri M. Dilating venous disease: pathophysiology and a systematic aspect to different vascular territories. Medical Hypotheses. 2016; (91): 73-76. https://doi.org/10.1016/j.mehy.2016.04.016
7. Darenskaya M.A., Stupin D.A., Semendyaev A.A., Kolesnikov S.I., Grebenkina L.A., Shcherbatykh A.V., et al. Comparative analysis of lipid peroxidation in peripheral and regional blood flow in women with primary pelvic varicose veins. Klinicheskaya laboratornaya diagnostika. 2022; 67(7): 374-380. (In Russian) https://doi.org/10.51620/0869-2084-2022-67-7-374-380
8. Dudley A.C., Griffioen A.W. Pathological angiogenesis: mechanisms and therapeutic strategies. Angiogenesis. 2023; (26): 313–347. https://doi.org/10.1007/s10456-023-09876-7
9. Chertok V.M., Chertok A.G., Zenkina V.G. Endothelial-dependent regulation of angiogenesis. Tsitologiya. 2017; 59(4): 243-258. (In Russian)
10. Batyrova A.S., Bakanov M.I., Surkov A.N. The state of the system of vascular remodeling and liver angiogenesis in chronic forms of its pathology. Patologicheskaya fiziologiya i eksperimental'naya terapiya. 2016; 60(1): 73-78. (In Russian)
11. Don E.E., Middelkoop M.A., Hehenkamp W.J., Mijatovic V., Griffioen A.W., Huirne J.A. Endometrial Angiogenesis of Abnormal Uterine Bleeding and Infertility in Patients with Uterine Fibroids—A Systematic Review. International Journal of Molecular Sciences. 2023; 24(8): 7011. https://doi.org/10.3390/ijms24087011
12. Cao Y., Langer R., Ferrara N. Targeting angiogenesis in oncology, ophthalmology and beyond. Nature Reviews Drug Discovery. 2023; 1-20. https://doi.org/10.1038/s41573-023-00671-z
13. Klabukov I.D., Balyasin M.V., Lyundup A.V., Krasheninnikov M.E., Titov A.S., Mudryak D.L., et al. Angiogenic vitalization of a biocompatible and biodegradable matrix (in vivo experimental study). Patologicheskaya fiziologiya i eksperimental'naya terapiya. 2018; 62(2): 53-60. (In Russian) https://doi.org/10.25557/0031-2991.2018.02.53-60
14. Darenskaya M.A., Stupin D.A., Semendyaev A.A., Kolesnikov S.I., Shcherbatykh A.V., Tolkachev K.S., et al. Pelvic venous insufficiency: lipid peroxidation levels in ovarian venous blood. Biomedical Research and Therapy. 2022; 9(2): 4884-4891. https://doi.org/10.15419/bmrat.v9i2.730
15. Darenskaya M.A., Semendyaev A.A., Stupin D.A., Kolesnikov S.I., Semenova N.V., Pesterev K.V., et al. Indicators of cellular and humoral immunity in peripheral and local bloodstreams in patients with primary varicose veins of the small pelvis. Infektsiya i immunitet. 2023; 13(2): 355-362. (In Russian) https://doi.org/10.15789/2220-7619-CAH-2108
16. Semendyaev A.A., Stupin D.A., Cherepanova M.A., Bachurina V.M., Seletskiy A.N., Kolesnikova L.I. A method for determining the functional state of the venous system of the pelvis in women. Patent 2646563, RF; 2018. (In Russian)
17. Kirova Yu.I., Germanova E.L. New aspects of the energy-tropic action of Mexidol. Patologicheskaya fiziologiya i eksperimental'naya terapiya. 2018; 62(4): 36-40. (In Russian) https://doi.org/10.25557/0031-2991.2018.04.36-40
18. Kondratovich L.M. A modern view on the etiology, pathogenesis and treatment of uterine fibroids. Rossiyskiy meditsinskiy zhurnal. 2014; (5): 36-40. (In Russian)
19. Yu D., Cai Y., Zhou W., Sheng J., Xu Z. The potential of angiogenin as a serum biomarker for diseases: systematic review and meta-analysis. Disease markers. 2018. https://doi.org/10.1155/2018/1984718
20. Pamuk A.E., Gedik M.E., Sutay Suslu N., Gunaydin G. Candidate Angiogenesis Related Biomarkers in Patients with Laryngeal Carcinoma (AngLaC): A Prospective Cohort Study. Otolaryngology–Head and Neck Surgery. 2023; 168(6): 1433-1442. https://doi.org/10.1002/ohn.219
21. Alotaibi F.T., Peng B., Klausen C., Lee A.F., Abdelkareem A.O., Orr N.L., et al. Plasminogen activator inhibitor-1 (PAI-1) expression in endometriosis. PLoS One. 2019; 14(7): e0219064. https://doi.org/10.1371/journal.pone.0219064
22. Schoeps B., Frädrich J., Krüger A. Cut loose TIMP-1: An emerging cytokine in inflammation. Trends in cell biology. 2023; 33(5): 413-426. Schoeps B., Frädrich J., Krüger A. Cut loose TIMP-1: An emerging cytokine in inflammation. Trends in cell biology. 2023; 33(5): 413-426. https://doi.org/10.1016/j.tcb.2022.08.005
23. Grünwald B., Schoeps B., Krüger A. Recognizing the molecular multifunctionality and interactome of TIMP-1. Trends in cell biology. 2019; 29(1): 6-19. https://doi.org/10.1016/j.tcb.2018.08.006
24. Cui N., Hu M., Khalil R.A. Biochemical and Biological Attributes of Matrix Metalloproteinases. Progress in Molecular Biology and Translational Science. 2017; (147): 1-73. https://doi.org/10.1016/bs.pmbts.2017.02.005.
25. Kwon M.J. Matrix metalloproteinases as therapeutic targets in breast cancer. Frontiers in Oncology. 2023; (12): 1108695. https://doi.org/10.3389/fonc.2022.1108695
26. Demirtaş H., Doğan A. Pelvic congestion syndrome. International Academic Research and Reviews in Health Sciences. 2023; (123).
27. Hosaka K., Yang Y., Seki T., Du Q., Jing X., He X., et al. Therapeutic paradigm of dual targeting VEGF and PDGF for effectively treating FGF-2 off-target tumors. Nat Commun. 2020; (11): 3704. https://doi.org/10.1038/s41467-020-17525-6
28. Yu P., Wilhelm K., Dubrac A., Tung J.K., Alves T.C., Fang J.S. et al. FGF-dependent metabolic control of vascular development. Nature. 2017; (545): 224–228. https://doi.org/10.1038/nature22322
29. Darenskaya M.A., Semendyaev A.A., Stupin D.A., Kolesnikov S.I., Semenova N.V., Pesterev K.V. et al. Pro- and Anti-Inflammatory Blood Cytokines Levels in Women with Moderate and Severe Pelvic Venous Insufficiency. Journal of Biomedicine. 13(1): 54-57. http://dx.doi.org/10.21103/Article13(1)_OA5 I
30. Ricci S. Varicose veins in women with Pelvic Congestion Syndrome: the hypothesis of the hormonal pathogenesis. Journal of Theoretical and Applied Vascular Research. 2018; 3(3).
Published
2024-06-20
How to Cite
Semendyaev A. A., Darenskaya M. A., Stupin D. A., Kolesnikov S. I., Semenova N. V., Tukhieva D. V., Kolesnikova L. I. Evaluation of serum angiogenesis factors in patients with pelvic venous incompetence // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2024. VOL. 68. № 2. PP. 20–27.
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Section
Original research
