Enhancing the effect of stem cell therapy by healthy donor total lymphocyte RNA support

Abstract

It is obvious that stem cells in the body require particularly strict regulation of their activity by integral systems. Previous analysis of the cellular pathogenesis of various diseases and its relationship with disorders of the T-lymphocyte regulation showed that, in pathological conditions, there are always functional disorders in a series of morphogenetic reparative T-lymphocytes that control the homeostasis. Previously, in vivo and in vitro experiments have provided qualitative and quantitative evidence that regulatory properties of total RNA from the spleen, thymus or peripheral blood lymphocytes are consistent with the properties of the lymphocytes themselves, and these properties are manifested in recovery processes of organs and tissues. It has also been shown that preparations of total RNA from allogeneic or xenogeneic lymphocytes of a healthy donor contribute to the “reprogramming” of the recipient’s lymphocytes, their normalization, and, thus, the restoration of impaired functions in experimental animals. Accordingly, we suggest to precede the administration of stem cells by the administration of total RNA from lymphoid cells of healthy donors to enhance the recovery of disordered functions of a specific organ system.