A comparative study of the antiarrhythmic activity of anxiolytics, benzodiazepine and benzimidazole derivatives, in a model of electrical ventricular fibrillation

Abstract

Aim. To compare the antiarrhythmic activity of fabomotizole and benzodiazepine derivatives (phenazepam and diazepam) in electrical ventricular fibrillation modeled in rats with intact and denervated myocardium. Methods. In experiments on intact rats and rats with denervated myocardium, the antiarrhythmic activity of the anxiolytics, benzodiazepine (phenazepam and diazepam) and benzimidazole (fabomotizole) derivatives, was compared. Results. It was shown that phenazepam (1.0 mg/kg, i.v.) and fabomotizole (7.5 mg/kg, i.v.) administered to intact animals, in contrast to diazepam (0.5 and 1.0 mg/kg, i.v.), significantly (p=0.028) increased the electrical ventricular fibrillation threshold. In animals with denervated myocardium, only fabomotizole showed an antifibrillatory activity (p<0.05). Conclusion. It can be assumed that phenazepam implements its antiarrhythmic activity mainly at the level of the central nervous system whereas fabomotizole produces it at the level of the myocardium.