Fulleren C₆₀ influence on lipids free-radical processes at bronchial asthma

Abstract

Lipids peroxidative oxidation as well as antioxidative enzymes superoxidedismutase and catalase activity state at the mice sensibilization with ovalbumine, its correction with fulleren FC₆₀ as well as by its forms (FC₆₀-OVA, mFC₆₀ mFC₆₀-OVA) modified and conjugated with ovalbumines have been studied. It has been demonstrated that the mice sensibilization with ovalbumin leads to the tissues peroxidative lipid oxidation processes enforcement as well as lowering antioxidative enzymes activity in lungs and spleen. Used different rulleren forms expressed antioxidative effect and modifying effect to antioxidative protection enzymes at a given pathology. The influence of fulleren FC₆₀ and its modified form (1,2-methanofulleren-C₆₀)-61-carbolacid was the mostly effective. The data recieved testify to the prospects of the fullerens further investigation as the potential medicines.