Influence of Haloperidol on changes in catalepsy development reaction during subchronic injections of dopamine agonists and antagonists

Abstract

The influence of haloperidol intracutaneous injections on the development of spontaneous catalepsy phenomenon in SHR mice which received intraperitoneal injections of d,l-amphetamine (10 mg/kg) and haloperidol (5 mg/kg) alternately during 12 days, was studied («neurochemical aggression»). It was demonstrated that alternating injections of d,l-amphetamine and haloperidol decrease the spontaneous catalepsy duration. Daily intracutaneous injections of haloperidol (0,25 mg/kg) prevented these changes but disrupted the spontaneous catalepsy phenomenon recovery by the 10-th day of measurements. A lower dosage (0,1 mg/kg) of haloperidol did not affect the results of the research. A conclusion was made that subchronic injections of haloperidol might have a protective effect in acute period of «neurochemical aggression» but slow down brain functioning recovery.