The comparison of antiamnestic action of antibodies to glutamate and neuropeptide Semax in the focal ischemic damage of prefrontal cortex of rat brain

  • G.A. Romanova Institute of General Pathology and Pathophysiology, 8, Baltiyskaya str., 125315, Moscow, Russia
  • F.M. Shakova Institute of General Pathology and Pathophysiology, 8, Baltiyskaya str., 125315, Moscow, Russia
  • T.V. Davudova Institute of General Pathology and Pathophysiology, 8, Baltiyskaya str., 125315, Moscow, Russia
Keywords: bilateral photothrombosis, prefrontal cortex, peptide semax, AB-Glu, intranasal injection

Abstract

It was stated, that with bilateral photochemically induced thrombosis of the prefrontal cortex peptide semax and the AB-Glu by intranasal injection provoke pronounced neuroprotective and antiamnestic action. Intranasal injection semax (250 mkg/kg/daily during six postoperative days) and AB-Glu (250 mkg/kg in 1 hour after phototrombosis) demonstrate diminishing of cortex damage volume and relieve preservation and reproduction rat passive avoidance reflex, acquired before bilateral photochemically induced thrombosis of prefrontal cortex.

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Published
2012-12-20
How to Cite
Romanova G., Shakova F., Davudova T. The comparison of antiamnestic action of antibodies to glutamate and neuropeptide Semax in the focal ischemic damage of prefrontal cortex of rat brain // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2012. VOL. 56. № 3. PP. 62–67.
Issue
Vol. 56 No. 3 (2012)
Section
Original research