Comparative hepato- and endotelioprotective effect of remaxol and S-adenosyl-L-methionine in experimental defeat of a liver by antituberculosis essential drugs in a combination to alcohol

  • D.S. Sukhanov I.I. Mechnikov North-Western State Medical University, 41, Kirochnayastr., Saint-Petersburg, 191015, Russia
  • E.B. Artyushkova Ecological Medicine Institute of Kursk State Medical University, 3, Karl Marks str., Kursk, 305041, Russia
  • V.T. Dudka Kursk State Medical University, 3, Karl Marks str., Kursk, 305041, Russia
Keywords: antituberculosis drugs, remaxol, S-adenosyl-L-methionine, endotelioprotective activity, hepatoprotective activity

Abstract

Introduction within 12 days of antituberculosis drugs: the isoniazid, rifampicin, pyraxinamide in a combination to alcohol leads to heavy toxic defeat of the liver, being accompanied characteristic dynamics of histologic and biochemical markers in a combination to development of endotelial dysfunction against normal for this type of animal values of arterial pressure. Application of remaxoland S-adenosyl-L-methionine reduces histologic symptoms of fatty dystrophy of a liver, bringing biochemical indicators into limits of physiological norm for this species of animals. Hepatoprotective activity is more expressed at application of remaxol. Studied medicians possess the expressed endotelioprotective activity on the chosen model of pathology and lead to decrease in factor of endotelial dysfunction and its approach to level of intact animals.

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Published
2012-12-20
How to Cite
Sukhanov D., Artyushkova E., Dudka V. Comparative hepato- and endotelioprotective effect of remaxol and S-adenosyl-L-methionine in experimental defeat of a liver by antituberculosis essential drugs in a combination to alcohol // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2012. VOL. 56. № 4. PP. 128–131.
Issue
Vol. 56 No. 4 (2012)
Section
Original research