Disturbances of the control mechanisms over immune and liver cell responce to endotoxin and their role in pathogenesis of the alcohol-induced liver diseases. Hypothesis of Dual Strike

  • L.F. Panchenko Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, 125315, Moscow, 8 Baltiyskaya str.; National Research Center for Addiction Medicine, Ministry of Health of the Russian Federation, 3, M. Mogiltsevsky Lane, Moscow, 119002
  • S.V. Pirozhkov National Research Center for Addiction Medicine, Ministry of Health of the Russian Federation, 3, M. Mogiltsevsky Lane, Moscow, 119002; Sechenov Moscow Medical Academy. I.M. Sechenov Moscow Medical Academy, Department of Pathophysiology
  • N.N. Terebilina National Research Center for Addiction Medicine, Ministry of Health of the Russian Federation, 3, M. Mogiltsevsky Lane, Moscow, 119002
  • T.A. Naumova National Research Center for Addiction Medicine, Ministry of Health of the Russian Federation, 3, M. Mogiltsevsky Lane, Moscow, 119002
  • V.J. Baronetz National Research Center for Addiction Medicine, Ministry of Health of the Russian Federation, 3, M. Mogiltsevsky Lane, Moscow, 119002
  • B.B. Shoibonov Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, 125315, Moscow, 8 Baltiyskaya str.; National Research Center for Addiction Medicine, Ministry of Health of the Russian Federation, 3, M. Mogiltsevsky Lane, Moscow, 119002
  • N.N. Merzhlikina Department of Hospital Therapy, Faculty of Medicine, N.I. Pirogov Russian State Medical University, Moscow
  • A.S. Zhuravleva Department of Hospital Therapy, Peoples Friendship University of Russia, Moscow
Keywords: alcohol-induced liver diseases, T regulatory cells, cytokines, lipoproteins, foam cells, NO-synthase, macrophage phenotypes

Abstract

Immune cells and plasma components controlling over reaction to endotoxin in alcohol-induced liver diseases (ALD) (alcohol hepatitis, liver cirrhosis and acute attack of hepatitis with liver cirrhosis) have been studied and compared with markers of inflammatory and fibroid hepatopathology (cytokines, immunocellular, biochemical and clinical indicators of hepatocellular damage). Our data support a role for deficiency of T regulatory cells and plasma components suppressing inflammatory potential of endotoxin (high density lipoproteins and albumin) coupled with hyperproduction of proinflammatory multi-modified low density lipoproteins (mmLDL) and C-reactive protein in ALD progression. Association of mmLDL with switching tolerogenic phenotype of macrophage to inflammatory and NO-synthase -deficient phenotypes and Th17-dependent inflammatory reaction has been showed.

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Published
2012-12-20
How to Cite
Panchenko L., Pirozhkov S., Terebilina N., Naumova T., Baronetz V., Shoibonov B., Merzhlikina N., Zhuravleva A. Disturbances of the control mechanisms over immune and liver cell responce to endotoxin and their role in pathogenesis of the alcohol-induced liver diseases. Hypothesis of Dual Strike // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2012. VOL. 56. № 4. PP. 117–127.
Issue
Vol. 56 No. 4 (2012)
Section
Original research