Pathophysiological mechanisms of influence of exogenous nitrogen monoxide polypous rhinosinusitis

  • E.I. Astashkin Federal State Budgetary Educational Institution of Higher Professional Education "I.M. Sechenov First Moscow State Medical University. I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, 8 Trubetskaya St., bld. 2, Moscow, 119991
  • A.V. Shirokaya State Budgetary Healthcare Institution of the Moscow Region, Moscow Regional Clinical Research Institute named after I.M. Sechenov, Ministry of Healthcare of the Russian Federation, 119991, Moscow, ul. M.F. Vladimirskikh, 61/2 Shchepkina St., Moscow, 129110
  • N.D. Yegorova Federal State Budgetary Educational Institution of Higher Professional Education "I.M. Sechenov First Moscow State Medical University. I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, 8 Trubetskaya St., bld. 2, Moscow, 119991
  • N.S. Orekhova Federal State Budgetary Educational Institution of Higher Professional Education "I.M. Sechenov First Moscow State Medical University. I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, 8 Trubetskaya St., bld. 2, Moscow, 119991
  • A.N. Novikova Federal State Budgetary Educational Institution of Higher Professional Education "I.M. Sechenov First Moscow State Medical University. I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, 8 Trubetskaya St., bld. 2, Moscow, 119991
  • A.N. Nasedkin State Budgetary Healthcare Institution of the Moscow Region, Moscow Regional Clinical Research Institute named after I.M. Sechenov, Ministry of Healthcare of the Russian Federation, 119991, Moscow, ul. M.F. Vladimirskikh, 61/2 Shchepkina St., Moscow, 129110
  • S.V. Grachev Federal State Budgetary Educational Institution of Higher Professional Education "I.M. Sechenov First Moscow State Medical University. I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, 8 Trubetskaya St., bld. 2, Moscow, 119991
Keywords: polypous rhinosinusitis, blood phagocytes, superoxide anion, nitric oxide, formil peptide

Abstract

By using the chemiluminescence method to evaluate the functional activity of the functional state of phagocytes blood patients with polypous rhinosinusitis. It was evaluated the ability of phagocytes generate superoxide anion. emonstrates how to change the primary immune cells respond to standard activator (formil peptide) when exposed to the nasal cavity nitrogen oxide. The research was performed in dynamics.

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Published
2012-12-20
How to Cite
Astashkin E., Shirokaya A., Yegorova N., Orekhova N., Novikova A., Nasedkin A., Grachev S. Pathophysiological mechanisms of influence of exogenous nitrogen monoxide polypous rhinosinusitis // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2012. VOL. 56. № 4. PP. 109–112.
Issue
Vol. 56 No. 4 (2012)
Section
Original research