The treat effect of liposomes during haemorrhagic shock (experimental research)

Abstract

In experiences on the cats subjected to haemоrrhagic shock, it is established the correction effect of phosphatidylcholine-containing liposomes on structure of lungs, a liver, a brain and a spleen. It is shown, that liposomes possess antioxidant action and are capable to restore the damaged phospholipid bilayer of cellular membranes. Application of liposomes at a late stage of haemоrrhagic shock causes on the average during 30 mines increase of arterial pressure on the average to 70 mm hg (to level at which the further destruction of cells stops). Stabilisation of arterial pressure at subnormal level observed on the average during 4 ч. Animals viability increased on the average at 7 o’clock. Liposomes applied in small volume (1 ml/kg) and can be used for rendering of the first medical aid at early and late stages of haemоrrhagic shock, and also in complex therapy of haemоrrhagic shock.