Protein profiles changes of human aorta intima and media in atherosclerosis process

  • I.A. Sobenin Institute for General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia, Institute for Atherosclerosis Research, Skolkovo Innovative Centre, 100, Novaya str., Moscow, 143025, Russia
  • N.S. Zhukovsky Institute for General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia
  • V.P. Karagodin Plekhanov Russian University of Economics, 36, Stremyanny per., Moscow, 117997, Russia
  • L.I. Kovaljev Bach Institute of Biochemistry RAS, 33, Leninsky prospekt, Moscow, 119071, Russia
  • V.A. Myasoedova Institute for Atherosclerosis Research, Skolkovo Innovative Centre, 100, Novaya str., Moscow, 143025, Russia, Research Center for Cardiology, 4, via Parea, Milan, 20138, Italy
  • K. Banfy Research Center for Cardiology, 4, via Parea, Milan, 20138, Italy
  • S.S. Shishkin Bach Institute of Biochemistry RAS, 33, Leninsky prospekt, Moscow, 119071, Russia
  • A.N. Orekhov Institute for General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia, Institute for Atherosclerosis Research, Skolkovo Innovative Centre, 100, Novaya str., Moscow, 143025, Russia
Keywords: atherosclerosis, proteomics, aorta, protein profile

Abstract

The present study was undertaken in order to examine association between various stages of atherosclerotic lesion and protein maps of human aorta intima and media. The results of the two dimensional electrophoresis of intima and media demonstrate protein profiles of various stages of atherosclerotic lesion (initial stages, lipid strips, lipofibrous plaques, fibrous plaques) versus controls (unaffected aorta sites). Protein spots that have been differentially expressed were found under unaffected intima and media sites versus lipofibrous plaques. Some of these proteins were identified using matrix assisted desorption ionisation time of flight (MALDI-TOF) mass spectrometry.

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Published
2012-12-20
How to Cite
Sobenin I., Zhukovsky N., Karagodin V., Kovaljev L., Myasoedova V., Banfy K., Shishkin S., Orekhov A. Protein profiles changes of human aorta intima and media in atherosclerosis process // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2012. VOL. 56. № 4. PP. 54–61.
Issue
Vol. 56 No. 4 (2012)
Section
Original research