Endothelial progenitor cells in umbilical cord-derived mezenhimosferoids and their participation in the processes of angiogenesis and vasculogenesis in acute liver failure

  • A.A. Gorkun The Institute of General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., 125315, Moscow, Russia
  • I.N. Saburina The Institute of General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., 125315, Moscow, Russia
  • N.V. Kosheleva The Institute of General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., 125315, Moscow, Russia
  • I.M. Zurina The Institute of General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., 125315, Moscow, Russia
  • A.A. Pulin The Institute of General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., 125315, Moscow, Russia
  • M.Iu. Shagidulin Institute of Transplantology and Artificial Organs, 1, Schukinskaya str., Moscow, 123182, Russia
  • N.A. Onischenko Institute of Transplantology and Artificial Organs, 1, Schukinskaya str., Moscow, 123182, Russia
  • V.S. Repin The Institute of General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., 125315, Moscow, Russia
Keywords: 3D culture, MMSC, EPC, vasculogenesis, angiogenesis

Abstract

Our results show that vascular endothelial growth factor (VEGF) induces the appearance of endothelial progenitor cells (EPC) in spheroids of human umbilical cord-derived multipotent mesenchymal stromal cells (HUC-MMSC). EPC may taking part in the regeneration of blood vessels damaged organ. 1 month after xenogeneic transplantation spheroids observed in corporation of individual human Flk-1+ cells in the blood vessels of the recipient. We look forward to further experiments to find the optimal treatment conditions spheroids on liver regeneration through angiogenesis.

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Published
2012-12-20
How to Cite
Gorkun A., Saburina I., Kosheleva N., Zurina I., Pulin A., Shagidulin M., Onischenko N., Repin V. Endothelial progenitor cells in umbilical cord-derived mezenhimosferoids and their participation in the processes of angiogenesis and vasculogenesis in acute liver failure // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2012. VOL. 56. № 4. PP. 50–53.
Issue
Vol. 56 No. 4 (2012)
Section
Original research