Simulation of repeated local hemorrhagic stroke in rats

  • A.N. Makarenko Taras Shevchenko Kyiv national university, 2, prosp. Akademika Glushkova, Kyiv-022, 03022, Ukraine
  • S.G. Morozov Institute of General Pathology and Pathophysiology, 8, Baltiyskaya str., Moscow, 125315, Russia
  • S.I. Savosko Bogomoletz Institute of Physiology, 4, Bogomoletz str., Kyiv, 01024, Ukraine
  • I.G. Vasil`eva Institute of Neurosurgery named after A.P.Romodanov, Ukrainian Academy of Medical Science, 32б Platon Mayboroda str., Kiev, 04050, Ukraine
Keywords: repeated local hemorrhagic stroke, method/modeling, morphological features, rat brain

Abstract

The processes of developed in CNS the complicated stroke and developments of fittings for their pharmaceutical therapy were developed and offering by standardized method of the experimental secondary stroke in rats, suitable for the use in sharp and chronic researches. Variant of repeated hemorrhagic stroke consist of autohemorrhagic right hemisphere stroke by the mechanical damage of brain tissue after 10-daily occlusion of right common carotid artery was studied. A model is comfortable for reproducing of the repeated standardized local damage of brain, is more adequate form of design of transient and chronic cerebrovascular pathology, than the independent use of local hemorrhage of autoblood in the brain of animals. The morphological description of model approaches the clinical variants of development and flow of sharp hemorrhagic stroke after a previous chronic cerebral insufficiency on an ischemic type.

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Published
2013-01-21
How to Cite
Makarenko A., Morozov S., Savosko S., Vasil`eva I. Simulation of repeated local hemorrhagic stroke in rats // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2013. VOL. 57. № 1. PP. 81–85.
Issue
Vol. 57 No. 1 (2013)
Section
Methods