The mirochondrial lipid palmitate/Са²⁺-induced pore and its possible role in a degradation of nervous cells

  • K.N. Belosludtsev Institute of Theoretical and Experimental Biophysics of the Russian Academy Science, 3, Institutskaya str., Pushchino, Moscow Region, 142290, Russia; Pushchino State Institute of Natural Sciences, 3, Prospekt Nauki, Pushchino, Moscow Region, 142290, Russia
  • G.D. Mironova Institute of Theoretical and Experimental Biophysics of the Russian Academy Science, 3, Institutskaya str., Pushchino, Moscow Region, 142290, Russia; Pushchino State Institute of Natural Sciences, 3, Prospekt Nauki, Pushchino, Moscow Region, 142290, Russia
Keywords: Mitochondria, palmitic acid, lipid pore, neurodegradation

Abstract

The subject of the review is a new type of mitochondrial pore — a pore which has lipid nature and is induced by palmitic acid and Ca2+. The review considers molecular mechanisms of its formation and regulation, conditions of its opening in biological membranes and the role in physiological and pathophysiological processes. Also discussed is involvement of the lipid pore in glutamate-induced degradation of nervous cells.

Downloads

Download data is not yet available.
Published
2012-08-22
How to Cite
Belosludtsev K., Mironova G. The mirochondrial lipid palmitate/Са²⁺-induced pore and its possible role in a degradation of nervous cells // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2012. VOL. 56. № 3. PP. 20–32.
Issue
Vol. 56 No. 3 (2012)
Section
Problema