SKF-index as an indicator of biological age of hemostasis and blood vessels in children and adults in norm and pathology

Abstract

A novel noninvasive method of an assessment of the hemostasis system and the vascular walls functioning is proposed. This method is based on the methodology of dynamic light scattering (DLS). New index SKF, which is derived from the previously established relationship between the intravascular mobility of the erythrocytes and the biological age, has been introduced. We demonstrated that the degree of the severity of the diseases correlates with the SKF index. More specifically, an increased value of the SKF index was found for the groups with cardio-vascular, oncological diseases and diabetes mellitus. In addition we provided evidences that the SKF index depends on the blood and plasma viscosity related to activity stage of the hemostasis system as well as on the functioning of the vascular walls.