Hepato- and endothelioprotective action of runihol and ademetionine in experimental liver injury induced by TB drugs in combination with alcohol

  • D.S. Sukhanov State Budgetary Educational Institution of Higher Professional Education, North-West State Medical University named after I.I. Mechnikov, Ministry of Health of Russia (41 Kirochnaya St., St. Petersburg, 191015)
  • E.B. Artyushkova Scientific Research Institute of Ecological Medicine SBEE HPE Kursk State Medical University, Ministry of Health Care of Russia (3 K. Marx St., Kursk, 305041)
  • V.T. Dudka State Budgetary Educational Institution of Higher Professional Education Kursk State Medical University, Ministry of Health Care of Russia (3 K. Marx St., Kursk, 305041)
Keywords: antituberculosis drugs, liver injury, alcohol, runihol, ademethionine

Abstract

Hepato- and endothelioprotective action of runihol and ademetionine in 66 male rats with liver disease induced by essential and second-line antituberculosis drugs in combination with alcohol were studied. One-directed affirmative action study drugs, shown to reduce the level of biochemical markers of cytolysis and cholestasis in conjunction with a significant reduction in symptoms of fatty, hyaline droplet and hydropic degeneration. In this runihol had a more pronounced anticytolitic effect, while under the influence of ademethionine the normalization endothelial dysfunction was established.

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Published
2013-06-19
How to Cite
Sukhanov D., Artyushkova E., Dudka V. Hepato- and endothelioprotective action of runihol and ademetionine in experimental liver injury induced by TB drugs in combination with alcohol // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2013. VOL. 57. № 2. PP. 45–49.
Issue
Vol. 57 No. 2 (2013)
Section
Original research