Respiratory and cardiovascular responses to hypoxia under activation or blockade inhibitory transmission

  • N.V. Sanotskaya The Institute of General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia
  • D.D. Matsievskii The Institute of General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia
  • M.A. Lebedeva The Institute of General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia
Keywords: respiration, chemosensitivity, resistance to acute hypoxia, picrotoxin, aminophylline, ultrasound

Abstract

Respiratory rhythm changes and hypoxic ventilatory responses were studied in anesthetized albino rats after administration GABA and adenosine receptor antagonists. Intracisternal microinjection of picrotoxin induced pathological periodic breathing. Picrotoxin intravenous administration caused the increase of individual resistance to acute hypoxia. Aminophylline administration exerted the opposite effect. After pretreatment of hydroxybutyrate we observed different types of respiratory reactions to adenosine antagonist injection, which probably depended on the value of arterial blood pressure and cerebral hemodynamics.

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Published
2013-06-19
How to Cite
Sanotskaya N., Matsievskii D., Lebedeva M. Respiratory and cardiovascular responses to hypoxia under activation or blockade inhibitory transmission // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2013. VOL. 57. № 2. PP. 32–36.
Issue
Vol. 57 No. 2 (2013)
Section
Original research