The system of assessment of the severity of ultrasound epilepsy in rats

  • R.A. Kopaladze Federal State Budgetary Institution «Institute of general pathology and pathophysiology» of Russian Academy of Medical Sciences: 125315 Moscow, Baltijskaya 8, Russia
Keywords: ultrasound-induced epilepsy, rats, the severity of the seizure, convulsive seizure, 9-points scale, carbamazepine

Abstract

The method of induction of epileptic reactions in rats by ultrasound (24.3 kHz; 116dB) and the system of severity estimation of epileptic reaction was developed. Ultrasound — frequency above 20 kHz — absolutely silent for a person, may cause epileptic reaction in 3—9% of the rats. The possibility of using ultrasound — induced epilepsy in rats to evaluate anticonvulsant activity of drugs it is shown

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Published
2013-08-12
How to Cite
Kopaladze R. The system of assessment of the severity of ultrasound epilepsy in rats // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2013. VOL. 57. № 3. PP. 87–92.
Issue
Vol. 57 No. 3 (2013)
Section
Methods