Investigation of multyphytoadaptogene anti-radiation activity in mice

Abstract

The aim of the work was to elucidate the radioprotective activity of multyphytoadaptogene (MPA) in mice in various conditions of gamma radiation and MPA application. Males of СВА х С57ВL/6 F1 mice were given 15% MPA solution with drinking water 2 weeks before the radiating (preventive application), 2 weeks before and 2 weeks after the radiating (preventive and therapeutic application) and also 2 weeks after the radiating only (therapeutic application). Animals of control groups received radiation or were given 5% ethanol solution in drinking water in the same application schemes. MPA increased the mice survival in preventive, preventive and therapeutic as well as therapeutic applications after 7,5 Gy radiation (66,7; 66,4 and 40,2% correspondingly). Аfter 11,0 Gy radiation MPA increased the mice survival in preventive as well as preventive and therapeutic applications (75,0 and 76,9% correspondingly). MPA administration improved the somatic state, weight of animals, quality of life. MPA has no side effects. The data suggest the radioprotective activity of MPA.