The role of antibodies to neurotransmitters of antinociceptive system in mechanisms of neuropathic pain

  • S.I. Igonkina Institute of General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., 125315, Moscow, Russia
  • L.A. Vetrile Institute of General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., 125315, Moscow, Russia
  • M.L. Kukushkin Institute of General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., 125315, Moscow, Russia
Keywords: neuropathic pain, antinociceptive system, neurotransmitters, antibodies to GABA to GABA, serotonin, noradrenalin, dopamine

Abstract

The present investigation was undertaken in order to study the role of the antibodies to neurotransmitters of antinociceptive system in pathogenesis of neuropathic pain on models of neuropathic pain. It was shown that the development of experimental neuropathic pain syndrome is accompanied with induction of autoantibodies to GABA, serotonin, noradrenalin and dopamine. It was established that the antibodies to neurotransmitters of antinociceptive system have a pronociceptive effect.

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Published
2013-08-12
How to Cite
Igonkina S., Vetrile L., Kukushkin M. The role of antibodies to neurotransmitters of antinociceptive system in mechanisms of neuropathic pain // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2013. VOL. 57. № 3. PP. 32–36.
Issue
Vol. 57 No. 3 (2013)
Section
Original research