The saving role of glutamate antibodies with the acute ischemic damage of the rat brain prefrontal cortex

  • F.M. Shakova Institute of General Pathology and Pathophysiology RAMS, 8 Baltiyskaya str., Moscow, 125315, Russia
  • P.M. Klodt Institute of Pharmacology of the V.V. Zakusov RAMS, 8 Baltiyskaya str., Moscow, 125315, Russia
  • V.S. Kudrin Institute of Pharmacology of the V.V. Zakusov RAMS, 8 Baltiyskaya str., Moscow, 125315, Russia
  • T.V. Davydova Institute of General Pathology and Pathophysiology RAMS, 8 Baltiyskaya str., Moscow, 125315, Russia
  • G.A. Romanova Institute of General Pathology and Pathophysiology RAMS, 8 Baltiyskaya str., Moscow, 125315, Russia
Keywords: antibodies to glutamate, glutamate, neuromediatory aminoacids, photothrombosis, prefrontal cortex of brain, gippocampus, hypothalamus

Abstract

On the model of acute ischemic damage of prefrontal areas of the rats brain cortex was shown, that intranasal injection of glutamate antibodies over one hour after ischemic damage of brain prefrontal areas leads to diminishing of glutamate content in hippocampus and prefrontal cortex.

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Published
2013-08-12
How to Cite
Shakova F., Klodt P., Kudrin V., Davydova T., Romanova G. The saving role of glutamate antibodies with the acute ischemic damage of the rat brain prefrontal cortex // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2013. VOL. 57. № 3. PP. 19–22.
Issue
Vol. 57 No. 3 (2013)
Section
Original research