To the Fas-induced neurons apoptosis mechanisms in stroke pathogenesis

  • S.P. Sergeeva The First Sechenov Moscow State Medical University, 8-2, Trubetskaya str., Moscow, 119992, Russia
  • P.F. Litvickiy The First Sechenov Moscow State Medical University, 8-2, Trubetskaya str., Moscow, 119992, Russia
  • M.M. Gultyaev Evdokimov Moscow State University of Medicine and Dentistry, 20/1, Delegatskaya str., 127473, Russia
  • A.A. Savin Evdokimov Moscow State University of Medicine and Dentistry, 20/1, Delegatskaya str., 127473, Russia
  • I.D. Breslavich Lomonosov Moscow State University, 1-4, Leninskiye Gory, 119991, Russia
Keywords: stroke pathogenesis, apoptosis, sFas, sFasL, Fas, CD95

Abstract

The goal of the present study was to investigate the plasma levels of proteins regulating Fas-induced apoptosis in acute stroke and to relate ones to brain damage and clinical features. By means of ELISA soluble Fas receptor (sFas) and soluble Fas ligand (sFasL) plasma levels were detected. Fas protein (CD95) expression on CD3 lymphocytes surfaces was detected using flow cytometry. It is summarized, that Fas-induced apoptosis play significant role in stroke pathogenesis. As the result, prognostic significance of sFasL plasma level is showed. Fas induced apoptosis mechanisms seems to be perspective target for search new therapy stroke patients.

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Published
2013-08-12
How to Cite
Sergeeva S., Litvickiy P., Gultyaev M., Savin A., Breslavich I. To the Fas-induced neurons apoptosis mechanisms in stroke pathogenesis // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2013. VOL. 57. № 3. PP. 15–18.
Issue
Vol. 57 No. 3 (2013)
Section
Original research