Direct antiatherosclerotic therapy: possible approaches, results of clinical trials

  • V.A. Aladinsky Moscow Institute of Physics and Technology, 9, Institutskij per., Dolgoprudny, Moscow region, 141700, Russia; Skolkovo Innovations Centre, Institute for Atherosclerosis Research, Skolkovo Innovative Center, 143025, 100 Novaya Str., Moscow, Russia
  • N.G. Nikiforov Skolkovo Innovations Centre, Institute for Atherosclerosis Research, Skolkovo Innovative Center, 143025, 100 Novaya Str., Moscow, Russia; Russian Cardiology Research Center, 15a, 3rd Cherepkovskaya str., Moscow, 121552, Russia
  • V.A. Orekhova Skolkovo Innovations Centre, Institute for Atherosclerosis Research, Skolkovo Innovative Center, 143025, 100 Novaya Str., Moscow, Russia; Russian Cardiology Research Center, 15a, 3rd Cherepkovskaya str., Moscow, 121552, Russia
  • A.A. Melnichenko Skolkovo Innovations Centre, Institute for Atherosclerosis Research, Skolkovo Innovative Center, 143025, 100 Novaya Str., Moscow, Russia
  • V.P. Karagodin Skolkovo Innovations Centre, Institute for Atherosclerosis Research, Skolkovo Innovative Center, 143025, 100 Novaya Str., Moscow, Russia
  • I.A. Sobenin Skolkovo Innovations Centre, Institute for Atherosclerosis Research, Skolkovo Innovative Center, 143025, 100 Novaya Str., Moscow, Russia; The Institute for General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia
  • A.N. Orekhov Skolkovo Innovations Centre, Institute for Atherosclerosis Research, Skolkovo Innovative Center, 143025, 100 Novaya Str., Moscow, Russia; The Institute for General Pathology and Pathophysiology RAMS, 8, Baltiyskaya str., Moscow, 125315, Russia
Keywords: angiotensin-converting enzyme, antiatherosclerotic therapy, atherosclerosis, atherosclerosis imaging, calcium antagonists, HDL therapy, statins

Abstract

The paper discusses the main approaches to slowing the progression and еру regression of atherosclerosis. Lipid and non-lipid treatment of atherosclerosis described. The results of clinical studies of the effect of antiatherosclerotic agents are analyzed. The main indicator is the thickness of the intima-media complex of the carotid arteries as measured by ultrasonography.

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Published
2013-11-29
How to Cite
Aladinsky V., Nikiforov N., Orekhova V., Melnichenko A., Karagodin V., Sobenin I., Orekhov A. Direct antiatherosclerotic therapy: possible approaches, results of clinical trials // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2013. VOL. 57. № 4. PP. 76–83.
Issue
Vol. 57 No. 4 (2013)
Section
Reviews