The role of heat shock proteins in the pathogenesis of some components of metabolic syndrome. Literature review

Abstract

Studying metabolic syndrome (MS) has remained extremely important for a long time. The magnitude and increasing prevalence of pathological conditions that comprise this syndrome, such as obesity, arterial hypertension (AH), type 2 diabetes mellitus (T2DM), dyslipidemia, hyperinsulinemia, etc., have given MS a status of pandemic of the 21th century. Recently, for prevention and prognosis, most studies have focused on identifying risk factors for MS. This review analyzes the participation of heat shock proteins (HSPs) in various pathological processes emerging in MS. The knowledge of molecular mechanisms of MS pathogenesis plays an important role in developing a personalized approach for managing MS patients. Detailed studies of HSPs may allow using these proteins as possible targets in the development of MS treatments.