Pathogenesis as a problem of functional incompetence and imbalance in the population of T-lymphocytes

  • Nina M. Gevorkyan V.N. Orehovich Research Institute of Biomedical Chemistry, Pogodinskaya St. 10, Moscow 119121, Russian Federation; V.N. Orehovich Research Institute of Biomedical Chemistry, Pogodinskaya St. 10, Moscow 119121, Russian Federation https://orcid.org/0000-0002-0386-4010
  • N.V. Tishevskaya South Ural State Medical University, Vorovskogo St. 64, Chelyabinsk 454092, Russian Federation https://orcid.org/0000-0002-4912-3111
DOI: https://doi.org/10.25557/0031-2991.2021.02.109-119
Keywords: pathogenesis, regeneration, lymphoid cells, total RNA, sanogenesis, personalized medicine

Abstract

This review provides an analysis of the cellular basis of the pathogenesis of various diseases in the light of the regulatory role of T-lymphocytes. The role of the polyclonal diversity of the population of T-lymphocytes, the special properties of these cells-representatives of the homeostatic system of the body, in physiological processes in health and disease is considered. Prospects for therapeutic and prophylactic effects associated with the use of total RNA of normal lymphoid cells of allogeneic and xenogenic origin are indicated. The possibility of creating, using lymphocytic total RNA, adequate models of human diseases for the development of personalized medicine is also indicated.

Downloads

Download data is not yet available.
Published
2021-06-30
How to Cite
Gevorkyan N. M., Tishevskaya N. Pathogenesis as a problem of functional incompetence and imbalance in the population of T-lymphocytes // Patologicheskaya Fiziologiya i Eksperimental’naya Terapiya (Pathological physiology and experimental therapy). 2021. VOL. 65. № 2. PP. 109–119.
Issue
Vol. 65 No. 2 (2021)
Section
Reviews