Никотинамид фосфорибозилтрансфераза – провоспалительная молекула, характеризующая тяжесть течения ревматоидного артрита

Y.V. Polyakova; L.E. Seewordova; Y.R. Akhverdyan; L.N. Shilova; B.V. Zavodovsky

doi:10.25557/0031-2991.2020.04.62-68

Y.V. Polyakova Research Institute for Clinical and Experimental Rheumatology, Zemlyachky Str. 76, Volgograd 400138, Russia https://orcid.org/0000-0002-3022-4166
L.E. Seewordova Research Institute for Clinical and Experimental Rheumatology, Zemlyachky Str. 76, Volgograd 400138, Russia https://orcid.org/0000-0002-0965-6060
Y.R. Akhverdyan Research Institute for Clinical and Experimental Rheumatology, Zemlyachky Str. 76, Volgograd 400138, Russia https://orcid.org/0000-0001-8010-6777
L.N. Shilova Volgograd State Medical University, Ploshchad Pavshikh Bortsov 1, Volgograd 400131, Russia https://orcid.org/0000-0002-0438-8554
B.V. Zavodovsky Research Institute for Clinical and Experimental Rheumatology, Zemlyachky Str. 76, Volgograd 400138, Russia; Volgograd State Medical University, Ploshchad Pavshikh Bortsov 1, Volgograd 400131, Russia https://orcid.org/0000-0002-8864-9570

DOI: https://doi.org/10.25557/0031-2991.2020.04.62-68

Keywords: Nicotinamide phosphoribosyltransferase, NAMPT, rheumatoid arthritis, inflammation, adipokines, cytokines

Abstract

Nicotinamide phosphoribosyltransferase (NAMPT) stimulates synthesis of matrix metalloproteinases and chemokines, which support synovial inflammation caused by leukocyte infiltration. A positive correlation between NAMPT and C-reactive protein confirms the role of NAMPT as an inflammatory mediator. Increased concentrations of NAMPT are considered stimulators of systemic inflammation.
The aim of this study was to evaluate serum concentrations of NAMPT in patients with rheumatoid arthritis.
Methods. Serum concentration of NAMPT was determined by indirect enzyme-linked immunosorbent assay with commercial kits (RaiBiotech, cat.# EIA-VIS-1) according to the manufacturer’s instructions.
Results. Elevated serum NAMPT was detected in 84.29% of patients. Rheumatoid arthritis patients with higher NAMPT concentrations significantly more likely had a higher activity score DAS28 (disease activity degree II), a high level of antibodies to citrullinated peptide vimentin, higher levels of C-reactive protein, and higher red blood cell sedimentation rate.
Conclusion. NAMPT can be regarded as an important component of the pathogenesis of rheumatoid arthritis and a candidate target molecule for therapy.

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Nicotinamide phosphoribosiltransftrase is a proinflammatori molecule characterizing severiti of rheumatoid arthritis

Abstract

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